View abstract. View abstract. Dooren JC. B., Dhande, L. A., and Rawat, M. S. Therapeutic evaluation of zinc and copper supplementation in acute diarrhea in children: double blind randomized trial. Ann NY Acad Sci 1992;669:314-6. View abstract. 1980;13(1):20-25. Results of a randomised controlled trial. However, it's possible that people with certain genes that make them susceptible to age-related vision loss might benefit from zinc supplements. Zeng, L. and Zhang, L. Efficacy and safety of zinc supplementation for adults, children and pregnant women with HIV infection: systematic review. Natl Institute of Health, 1996. Silliman CC, Peterson VM, Mellman DL, et al. Oral zinc in macular degeneration. J Nutr 2002;132:1860-4.. View abstract. Luabeya, K. K., Mpontshane, N., Mackay, M., Ward, H., Elson, I., Chhagan, M., Tomkins, A., Van den Broeck, J., and Bennish, M. L. Zinc or multiple micronutrient supplementation to reduce diarrhea and respiratory disease in South African children: a randomized controlled trial. My son benefited from taking zinc gluconate every day. Oral zinc in recurrent Erythema Nodosum Leprosum reaction. Hinojosa, J., Prosper, M., Primo, J., and Moles, J. R. [The effect of a single nighttime dose of zinc acexamate (ZAC) on basal and pentagastrin-stimulated gastric secretion]. O'Brien KO, Zavaleta N, Caulfield LE, et al. View abstract. View abstract. 2007;2(6):e541. View abstract. Acrodermatitis enteropathica in Saudi Arabia. Am J Clin Nutr 1985;41(2):285-292. Mahomed, K., Bhutta, Z., and Middleton, P. Zinc supplementation for improving pregnancy and infant outcome. Lepr India 1983;55:547-52. View abstract. Age-Related Eye Disease Study Research Group. Cunliffe WJ, Burke B, Dodman B, Gould DJ. PLoS.One. Fairbrother, K. J., Kowolik, M. J., Curzon, M. E., Muller, I., McKeown, S., Hill, C. M., Hannigan, C., Bartizek, R. D., and White, D. J. A., Musharrafieh, U. M., Tamim, H., and Hamadeh, G. N. Topical zinc oxide vs. salicylic acid-lactic acid combination in the treatment of warts. 2012 Dec 12;12:CD007991. View abstract. Am J Gastroenterol 1999;94:334-8. Zinc metabolism in rheumatoid arthritis: plasma and urinary zinc and relationship to disease activity. Sazawal S, Black RE, Menon VP, et al. Relevance of zinc in human sperm flagella and its relation to motility. Chem Senses 2000;25:659. Randomized, controlled trial of zinc supplementation in malnourished Bangladeshi children with acute diarrhea. Toxicology 1984;31:207-16. Li P, Xu J, Shi Y, Ye Y, Chen K, Yang J, Wu Y. Indian J Physiol Pharmacol. Schweiz.Med Wochenschr. Roy, S. K., Tomkins, A. M., Akramuzzaman, S. M., Chakraborty, B., Ara, G., Biswas, R., Islam, K. E., Khatun, W., and Jolly, S. P. Impact of zinc supplementation on subsequent morbidity and growth in Bangladeshi children with persistent diarrhoea. 2017 Jan;28(1):4-15. Pharm Weekbl Sci 1986;8:85-8. Management of Wilson's disease with zinc sulphate. Omu AE, Dashti H, Al-Othman S. Treatment of asthenozoospermia with zinc sulphate: andrological, immunological and obstetric outcome. Rosado, J. L., Lopez, P., Munoz, E., Martinez, H., and Allen, L. H. Zinc supplementation reduced morbidity, but neither zinc nor iron supplementation affected growth or body composition of Mexican preschoolers. View abstract. Liver disease in people who drink alcohol. Quintessence Int. Tie HT, Tan Q, Luo MZ, Li Q, Yu JL, Wu QC. View abstract. A. Topical zinc sulphate solution for treatment of viral warts. However, taking zinc does appear to improve mouth ulcers caused by chemotherapy in children and adolescents. Mansouri A, Hadjibabaie M, Iravani M, Shamshiri AR, Hayatshahi A, Javadi MR, Khoee SH, Alimoghaddam K, Ghavamzadeh A. Lead, zinc, and copper decorporation during calcium disodium ethylenediamine tetraacetate treatment of lead-poisoned children. Relationships between serum free fatty acids and zinc, and attention deficit hyperactivity disorder: a research note. Hidayat, A., Achadi, A., Sunoto, and Soedarmo, S. P. THe effect of zinc sulfate supplementation in children under three years of age with acute diarrhea in Indonesia. Lin, L. C., Que, J., Lin, K. L., Leung, H. W., Lu, C. L., and Chang, C. H. Effects of zinc supplementation on clinical outcomes in patients receiving radiotherapy for head and neck cancers: a double-blinded randomized study. Eby GA, Davis DR, Halcomb WW. In: Prasad AS (ed). Scholl, T. O., Hediger, M. L., Schall, J. I., Fischer, R. L., and Khoo, C. S. Low zinc intake during pregnancy: its association with preterm and very preterm delivery. Most studies using zinc for ADHD have taken place in the Middle East, where zinc deficiency is more common than in Western countries. 2016 Jul 5. Ann Pharmacother 1996;30:186-7. Zavaleta N, Caulfield LE, Garcia T. Changes in iron status during pregnancy in peruvian women receiving prenatal iron and folic acid supplements with or without zinc. Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. View abstract. Hepatology 2000;32(4 Pt 1):877. View abstract. View abstract. Zinc toxicity can be either acute, leading to short term side effects, or chronic, resulting in … WebMD does not provide medical advice, diagnosis or treatment. Effect of zinc therapy on neutrophil chemotaxis in psoriasis. Br J Dermatol 1977;97:561-6. Vitamin D-sensitive and quinacrine-sensitive zinc transport in human intestinal cell line Caco-2. Zinc citrate is approximately 34% zinc by weight. Taking this much can decrease your copper, iron and magnesium levels, reduce your body's immune function, and reduce your HDL (good cholesterol) level. 1993;83(1):55-56. Drugs 1976;11:45-54.. View abstract. Asthma. Colon cancer, rectal cancer. Bogden, J. D., Oleske, J. M., Lavenhar, M. A., Munves, E. M., Kemp, F. W., Bruening, K. S., Holding, K. J., Denny, T. N., Guarino, M. A., and Holland, B. K. Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly. The longer you “overdose” on zinc, the worse your side effects will be. A. Evidence-based prevention of childhood malnutrition. However, research assessing the effects of zinc for TREATING pneumonia once it develops shows conflicting. Cornea 1996;15(6):582-588. View abstract. Zinc deficiency and hyperprolactinaemia are not reversible causes of sexual dysfunction in uraemia. Zinc Side Effect #1: Stomach Problems Even those of us with resilient stomachs can encounter some substances that irritate us. Merchant HW, Gangarosa LP, Glassman AB, Sobel RE. View abstract. it doesn't bother me, it's just very annoying. View abstract. Zinc: consumption patterns and dietary recommendations. Ophthalmology. Absorption of zinc from wheat products fortified with iron and either zinc sulfate or zinc oxide. J Trace Elem Med Biol 1997;11:65-70. View abstract. Am J Clin Nutr 1998;68:442S-6S. Answered by Dr. Mark Fisher: Zinc for cold? Flynn A, Pories WJ, Strain WH, et al. Zoli A, Altomonte L, Caricchio R, et al. A. Yuen WC, Whiteoak R, Thompson RP. Flu (influenza). Int J STD AIDS. Lancet 3-17-2007;369(9565):927-934. Early research suggests that taking zinc twice daily for 7 days does not improve jaundice in newborns. Am J Med 2001;111:103-8. But it does seem to lower the optimal dose of ADHD medication that is needed. A historical review of progress in the assessment of dietary zinc intake as an indicator of population zinc status. Nutritional effects of oral contraceptive use: A review. However, zinc doesn't seem to help treat diarrhea in adults with HIV-related diarrhea. J Clin Hypertens 1987;3:405-8. Neurology 1984;34:1393-5. Med Hypotheses 1985;17:157-65. Zinc Sulfate (zinc sulfate)." View abstract. Accessed 11 November 2016. 2011;29(2):134-140. Adv Nutr. Nielsen FH, Milne DB. Research shows that taking zinc sulfate by mouth while undergoing radiation therapy helps prevent ulcers and swelling in the mouth caused by radiation treatments. Serum and hair zinc levels in epileptic children taking valproic acid. Dreno B, Trossaert M, Boiteau HL, Litoux P. Zinc salts effects on granulocyte zinc concentration and chemotaxis in acne patients. Taking zinc might reduce how often they need to go to the bathroom. Chung, C. S., Stookey, J., Dare, D., Welch, R., Nguyen, T. Q., Roehl, R., Peerson, J. M., King, J. C., and Brown, K. H. Current dietary zinc intake has a greater effect on fractional zinc absorption than does longer term zinc consumption in healthy adult men. On the background of a copper-rich diet, 15 mg/d of zinc probably doesn’t matter. View abstract. 1997;8(2 Spec No):62-66. Some early research suggests that taking zinc sulfate improves canker sores and prevents them from reappearing. Clin Nephrol 1982;17:254-7. AIDSinfo. Effects of zinc supplementation on endocrine outcomes in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Effects of zinc supplementation on efficacy of antidepressant therapy, inflammatory cytokines, and brain-derived neurotrophic factor in patients with major depression. Valery, P. C., Torzillo, P. J., Boyce, N. C., White, A. V., Stewart, P. A., Wheaton, G. R., Purdie, D. M., Wakerman, J., and Chang, A. Necrolytic acral erythema associated with hepatitis C effective treatment with interferon alfa and zinc. View abstract. Sharquie, K. E., Khorsheed, A. Altunbasak S, Biatmakoui F, Baytok V, et al. Paradiso, Galatioto G., Gravina, G. L., Angelozzi, G., Sacchetti, A., Innominato, P. F., Pace, G., Ranieri, G., and Vicentini, C. May antioxidant therapy improve sperm parameters of men with persistent oligospermia after retrograde embolization for varicocele? Tisdall FF, Brown A, Defries RD. Sazawal, S., Jalla, S., Mazumder, S., Sinha, A., Black, R. E., and Bhan, M. K. Effect of zinc supplementation on cell-mediated immunity and lymphocyte subsets in preschool children. BMC.Infect.Dis. J Rheumatol 1994;21:927-33. Hello, 50 mg of zinc is not too much. 2014 Jan;40(1):33-7. 2011;11:122. Acta Paediatr. View abstract. Research suggests that taking zinc by mouth helps improve weight gain and reduces infection rate in children and adolescents with leukemia. A hormonal disorder that causes enlarged ovaries with cysts (polycystic ovary syndrome or PCOS). J Nutr 1994;124:1060-4. Lessons learned from attempts to establish the blind in placebo-controlled trials of zinc for the common cold. View abstract. J.Clin.Dent. Grahn BH, Paterson PG, Gottschall-Pass KT, Zhang Z. Zinc and the eye. View abstract. Walker, C. L., Bhutta, Z. 2013 Aug;57(8):3640-4. Bhutta, Z. 2010;72(3):220. Giving zinc to underweight infants in developing countries seems to decrease the risk of death, prevent certain complications, and improve mental ability. Seminar in Dialysis 1989;2(4):253-259. Am J Med Sci 1981;282:68-74. Zinc tolerance test in uremia: effect of calcitriol supplementation. Acta Paediatrica 1999;88:550-2. BMJ 1985;290:603-4. Use of zinc supplements to reduce upper respiratory infections in United States Air Force Academy cadets. Fertil Steril 1999;71:1138-43. J Toxicol Clin Toxicol 1999;37:279-92. Potential public health impact of age-related eye disease study results: AREDS report no. View abstract. Breast feeding Manufacturer advises avoid; present in milk—may cause zinc-induced copper deficiency in infant. Lin, S. F., Wei, H., Maeder, D., Franklin, R. B., and Feng, P. Profiling of zinc-altered gene expression in human prostate normal vs. cancer cells: a time course study. Epilepsia 1992;33:555-7. Other research suggests that taking zinc can improve sperm shape in men with moderate enlargement of a vein in the scrotum (grade III varicocele). J Dermatolog.Treat. J Am Diet Assoc 1990;90:1089-93. Optimal administration schedule of cisplatin for bladder tumor with minimal induction of metallothionein. Antioxidant supplement and long-term reduction of recurrent adenomas of the large bowel. Zinc lozenges reduce the duration of common cold symptoms. U.S. Food and Drug Administration, June 16, 2009. Acta Paediatr. Fallah R, Sabbaghzadegan S, Karbasi SA, Binesh F. Efficacy of zinc sulfate supplement on febrile seizure recurrence prevention in children with normal serum zinc level: A randomised clinical trial. View abstract. Antiviral Res 2001;49:1-14.. View abstract. Mohan H, Verma J, Singh I, et al. Sandstrom B, Almgren A, Kivisto B, Cederblad A. Curr Ther Res 1998;59:595-607. It is usually quite easy for us to identify and avoid such substances, … Eur J Clin Nutr 2004;58:703-10. However, other conventional treatments may be more effective. Med Hypotheses 1993;40:182-5. 2013 May;40(5):505-13. Cochrane Database Syst Rev. Floersheim, G. L. and Lais, E. [Lack of effect of oral zinc sulfate on wound healing in leg ulcer]. Basnet S, Shrestha PS, Sharma A, Mathisen M, Prasai R, Bhandari N, Adhikari RK, Sommerfelt H, Valentiner-Branth P, Strand TA; Zinc Severe Pneumonia Study Group. Ann Otol Rhinol Laryngol 1991;100:647-9. Kumar A, Bagri NK, Basu S, Asthana RK. 2013 Jun 28;6:CD009415. Kidney Int Suppl 1983;16:S315-8. Sexual problems that prevent satisfaction during sexual activity. 2010;68(6):323-332. View abstract. Requirements and toxicity of essential trace elements, illustrated by zinc and copper. Expanded activity and utility of the new fluoroquinolones: a review. View abstract. View abstract. Taking zinc by mouth, alone or together with painkillers, has no effect on the progression of psoriatic arthritis. Yoshikawa F, Nakajima T, Hanada M, et al. A., Lewin, S. R., Wightman, F., Lee, M., Ravindran, T. S., and Paton, N. I. Am J Clin Nutr 1997;65:1460-4. Lack of beneficial effect of zinc sulphate in rheumatoid arthritis. 2015 Jan;122(1):212-5. Henkin RI, Foster DM, Aamodt RL, Berman M. Zinc metabolism in adrenal cortical insufficiency: effects of carbohydrate-active steroids. View abstract. Metabolism 1984;33:491-501. View abstract. Nephrol Dial Transplant 1989;4:888-92. Absorption of trace metals in the zinc-deficient rat. View abstract. View abstract. Failure of zinc gluconate in treatment of acute upper respiratory tract infections. View abstract. For type 2 diabetes: 25 mg of zinc gluconate has been taken twice daily for 8 weeks. Akram M, Sullivan C, Mack G, Buchannan N. What is the clinical significance of reduced manganese and zinc levels in treated epileptic patients? Hunt CD, Johnson PE, Herbel J, Mullen LK. View abstract. 3 4 5 Zinc at a dose of more than 50 mg daily might reduce levels of HDL ("good") cholesterol. View abstract. This information may not fit your specific health circumstances. Use of topical ascorbic acid and its effects on photodamaged skin topography. View abstract. Clin Infect Dis 2001;33:1865-70. Demetree, J. W., Safer, L. F., and Artis, W. M. The effect of zinc on the sebum secretion rate. Kristensen, M. B., Hels, O., Morberg, C. M., Marving, J., Bugel, S., and Tetens, I. 2007;46(4):427-430. PLoS.One. Am J Clin Nutr 1980;33:1517-21. Medicine (Baltimore) 2019;98(10):e14637. J Periodontol 1990;61:674-9. Sickle cell disease. Graham, R. M., James, M. P., and Bennett, S. Low concentration zinc sulphate solution in the management of recurrent herpes simplex infection. View abstract. Zinc gluconate contains 14.3% elemental zinc; 10 mg zinc gluconate contains 1.43 mg zinc. Zemel BS, Kawchak DA, Fung EB, et al. Hurrell RF. Br J Dermatol 1980;103:411-5. J.Pediatr. View abstract. Metab Pediatr Syst Ophthalmol 1989;12:80-2. Zinc status is not adversely affected by folic acid supplementation and zinc intake does not impair folate utilization in human subjects. Rahman MM, Wahed MA, Fuchs GJ, et al. Nazem MR, Asadi M, Jabbari N, Allameh A. Effects of an EDTA infusion on the urinary elimination of several elements in healthy subjects. View abstract. II. Zinc. Br J Dermatol 1989;121:497-502. Antimicrob Agents Chemother 1987;31:1263-5. Arch Ophthalmol 2001;119:1417-36. View abstract. Curr Opin.Clin Nutr Metab Care 2009;12(6):646-652. View abstract. Available at: https://online.wsj.com/article/SB124516778692319231.html#mod=djemHL?mg=com-wsj (Accessed 16 June 2009). Leibovici V, Statter M, Weinrauch L, et al. Zinc supplementation as adjunct therapy in children with measles accompanies by pneumonia: a double-blind, randomized controlled trial. View abstract. Sharma G, Lodha R, Shastri S, et al. Am J Clin Nutr 2007;85(5):1293-1300. Pharmacol Toxicol 1989;65:209-13. Association of long-term, excessive use of zinc-containing Poli-Grip products with myeloneuropathy and blood dyscrasias. Effect of zinc supplementation started during diarrhoea on morbidity and mortality in Bangladeshi children: community randomised trial. Int Urol Nephrol 1996;28:687-94. View abstract. View abstract. View abstract. Orris L, Shalita AR, Sibulkin D, et al. Treatment of Wilson's disease with zinc: XI. 2013 Dec 15;74(12):872-8. View abstract. Am J Clin Nutr 1997;66:639-42. Is topical zinc effective in the treatment of melasma? A pregnancy complication marked by high blood pressure and protein in the urine (pre-eclampsia). Acta Derm.Venereol. Intranasal zinc and anosmia: the zinc-induced anosmia syndrome. View abstract. Oral zinc as an adjunct to dapsone in lepromatous leprosy. Zinc gluconate is approximately 13% zinc by weight. Schiliro G, Russo A, Azzia N, et al. J Invest Dermatol 1986;86:715-6. View abstract. Tang X, Shay NF. View abstract. Taking zinc by mouth together with vitamins does not seem to improve AIDS diarrhea-wasting syndrome. A mild form of gum disease (gingivitis). Aydinok Y, Coker C, Kavakli K, et al. View abstract. Eczema (atopic dermatitis). Lancet 1971;2:1169-72. Sazawal, S., Black, R. E., Jalla, S., Mazumdar, S., Sinha, A., and Bhan, M. K. Zinc supplementation reduces the incidence of acute lower respiratory infections in infants and preschool children: a double-blind, controlled trial. Still, consuming over 40 to 60 mg/day may lead to certain zinc overdose side effects, so speak to your health care professional before increasing your dosage. American Druggist 1996 Jul;42-8. Pories, W. J., Henzel, J. H., Rob, C. G., and Strain, W. H. Acceleration of wound healing in man with zinc sulphate given by mouth. American Journal of Tropical Medicine and Hygiene 1997;57(3 Suppl/1):434. View abstract. View abstract. (See Reference 3 and … Psoriatic arthritis treated with oral zinc sulphate. Medically reviewed by Drugs.com. 2016;8(3). Physiol Behav 1993;53:587-92. Blostein-Fujii A, DiSilvestro RA, Frid D, et al. Am J Clin Nutr. Zinc side effects can become potentially serious if you take doses from 150 to 450 mg a day. View abstract. Zittel S, Ufer F, Gerloff C, Münchau A, Rosenkranz M. Severe myelopathy after denture cream use--is copper deficiency or excess zinc the cause? Howie S, Bottomley C, Chimah O, et al. View abstract. Eur.J Clin Nutr 1997;51(1):33-37. Zinc as an adjunct to antibiotics for the treatment of severe pneumonia in children <5 years: a meta-analysis of randomised-controlled trials. View abstract. [A multicenter, clinical trial. J Diabetes Complications. View abstract. Lazzerini, M. and Ronfani, L. Oral zinc for treating diarrhoea in children. Mahalanabis D, Chowdhury A, Jana S, et al. View abstract. Lazzerini, M. and Ronfani, L. Oral zinc for treating diarrhoea in children. American Rhinologic Society 49th Annual Fall Scientific Meeting abstract. Effect of foodstuffs on the absorption of zinc sulfate. View abstract. J Am Coll Nutr 1988;7:57-60. View abstract. View abstract. Equivalent uptake of organic and inorganic zinc by monkey kidney fibroblasts, human intestinal epithelial cells, or perfused mouse intestine. But at doses higher than this, I would supplement with copper at an approximately 10:1 ratio (give or take). View abstract. 1999;21(4):271-281. Dutta, P., Mitra, U., Datta, A., Niyogi, S. K., Dutta, S., Manna, B., Basak, M., Mahapatra, T. S., and Bhattacharya, S. K. Impact of zinc supplementation in malnourished children with acute watery diarrhoea. View abstract. 2003;55(6):1143-1147. Seizures. A. V., and Andrade, I. C. Zinc hyaluronate effects on ulcers in diabetic patients [Spanish]. View abstract. View abstract. View abstract. Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapy. Taking zinc acexamate by mouth seems to help treat and prevent peptic ulcers. J Pediatr 2010;156(6):960-4, 964. J Natl Cancer Inst 1985;74:263. Reduced brain function in people with advanced liver disease (hepatic encephalopathy). Am J Clin Nutr. 2013 Aug;120(8):1604-11.e4. Illness from a Shigella bacteria infection (shigellosis). Bad breath. View abstract. Prasad AS, Fitzgerald JT, Bao B, et al. 1997;34(7):589-597. View abstract. View abstract. Prenatal iron supplements impair zinc absorption in pregnant Peruvian women. 2014 Jun;121:17-8. Greenberg JE, Lynn M, Kirsner RS, et al. Am J Clin Nutr 2002;75:2-3. Uysal Z, Akar N, Kemahli S, et al. Bobat, R., Coovadia, H., Stephen, C., Naidoo, K. L., McKerrow, N., Black, R. E., and Moss, W. J. 2008;43(3):281-287. Haider, B. The effectiveness of interventions to treat severe acute malnutrition in young children: a systematic review. Mery C, Delrieu F, Ghozlan R, et al. Kajanachumpol, S., Srisurapanon, S., Supanit, I., Roongpisuthipong, C., and Apibal, S. Effect of zinc supplementation on zinc status, copper status and cellular immunity in elderly patients with diabetes mellitus. If you consume 100 mg – 500 mg per day, you will experience serious side effects. Cochrane.Database.Syst.Rev. View abstract. Early research shows that taking zinc twice daily for 9 months helps the heart to beat more effectively in people who have had a heart attack. Erythromycin and zinc in ulcerative colitis ), Jorgensen PJ, Grandjean P. excretion! Hematopoietic stem cell transplantation ( HSCT ) alopacia areata- a double-blind, placebo-controlled trial soc Sci 2007..., Szabo G, Brazzelli V, Vignati G, Turner SW, Craig LC, et.... Medical treatment, taking zinc twice daily for 6 weeks reduce upper respiratory tract infections in children zinc 50 mg side effects elemental! 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